Everything about ceesdekker.net

Midway by his profession, Cees Dekker reinvented himself. Just after several years of hardcore physics, he shifted his emphasis to ‘nanobiology’ at the change of your millennium. A expression he coined himself, as a subject of reality.

Our team reports bacterial cell division and it is aiming to represent a ‘base up biology’ in synthetic cells that can autonomously divide. Our most important fascination lies in cell division, chromatin structure, and spatial Command.

The next articles or blog posts are merged in Scholar. Their put together citations are counted just for the first write-up.

Nanofabrication of electrodes with sub-five nm spacing for transport experiments on one molecules and metal clusters

We create point-of-treatment diagnostics examination of neglected tropical illnesses within useful resource-minimal settings, based on Crspr/Cas9 detecting of pathogen’s DNA in system fluids.

Case in point (three) of bending configurations in 3D simulations of DNA rods on nanopores. A portion of the membrane is demonstrated in grey, the rim of your pore is highlighted in crimson, along with a 3D rendering of the movement from the DNA rod is exhibited.

Considering the fact that 2000 he moved to solitary-molecule biophysics and nanobiology, with analysis from DNA supercoiling scientific studies of nucleosomes and DNA restore proteins to DNA translocation through nanopores. Recently his investigate has centered on studying mobile division with microorganisms on chip, although his ultimate desire is while in the path of knowing artificial cells.

Circulation-pushed rotary motors for instance windmills and water wheels drive functional processes in human Culture. Despite the fact that samples of these types of rotary motors also characteristic prominently in cell biology, their synthetic development for the nanoscale has remained complicated. In this article we demonstrate movement-driven rotary motion of a self-organized DNA nanostructure which is docked onto a nanopore in a thin sound-condition membrane. An elastic DNA bundle self-assembles into a chiral conformation upon phoretic docking onto the strong-state nanopore, and subsequently displays a sustained unidirectional rotary motion of up to 20 rev s−one.

The rotors harness Power from the nanoscale drinking water and ion movement that is created by a static chemical or electrochemical prospective gradient in the nanopore, which happen to be recognized through a salt gradient or used voltage, respectively. These artificial nanoengines self-Manage and work autonomously in physiological problems, suggesting methods to developing Vitality-transducing motors at nanoscale interfaces.

It was through this era that Dekker carried out investigate on magnetic spin methods and on noise in superconductors and semiconductors.

An integrated microfluidic platform for quantifying drug permeation across biomimetic vesicle membranes

2006, initial demonstration of molecular sorting in a very lab on a chip employing biomotors; discovery of nanobubbles in good-state nanopores; and 1st estimate of electrokinetic energy conversion within a nanofluidic channel

Permit’s to start with look back in the intervening time after you made a decision to shift your concentrate from superconductivity and nanotubes to biology at the end of the ceesdekker.net nineties.

2004, discovery of latest physics in translocation of DNA via nanopores; to start with experimental review of ions conduction in nanofluidic channels; 1st electrochemistry with person one-wall carbon nanotubes; STM detection and control of phonons in carbon nanotubes; initial electrical docking of microtubules on kinesin-coated nanostructures; to start with biophysics characterization on the mechanical Qualities of double-stranded RNA; and to start with solitary-molecule study of DNA translocation by a restriction-modification enzyme.